Viral Infection Mac OS

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  1. Viral Infections List
  2. Viral Infection Mac Os Catalina
  3. How Do You Get Viral Infections
  4. Types Of Viral Infections

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Mycobacterium Avium-Intracellulare; MAI; Mycobacterium Avium; Mycobacterium Avium-Intracellulare; MAI; Mycobacterium Avium; Mycobacterium Avium-Intracellulare infectionSee More
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Mycobacterium avium complex (MAC) refers to infections caused by two types of bacteria: Mycobacteriumavium and Mycobacteriumintracellulare.[1][2] MAC bacteria do not make most people sick. However, people with immune systems that do not work well (from HIV/AIDS or certain cancers for example) or people with lung disease (such as chronic obstructive pulmonary disease (COPD) or cystic fibrosis) are at the greatest risk for getting sick from MAC Infections. Elderly women are also at higher risk to get sick from MAC infections.[2][3]
There are 3 types of MAC infections.
  • Pulmonary MAC infections - Affect the lungs and are the most common type. These mainly affect elderly women and people who already have lung disease.[2][3]
  • Disseminated MAC infections - Have spread throughout the body. This type is usually seen in people with advanced AIDS.[1]
  • MAC-associated lymphadenitis - Causes swelling of the lymph nodes (especially in the neck) and is the most common in young children who have normal immune systems.[3][4]
While the symptoms are different for each type of infection, general symptoms include fever, night sweats, weight loss, and fatigue. MAC bacteria are found in water, soil, and dust. They infect people when the bacteria are inhaled or swallowed.[1][5] MAC bacteria are not usually spread from person to person. MAC infections are diagnosed by a combination of imaging scans and identifying the bacteria in cultures of cells from the infected area. Treatment for MAC infection depends on the type and may include antibiotics, antiviral medications, or surgery.[1][2]
Last updated: 11/8/2018
Mycobacterium avium complex infections can cause various symptoms depending on the site of the infection. For example, pulmonary MAC mainly affects the lungs; disseminated MAC affects the whole body; and MAC lymphadenitis causes swollen lymph nodes.[1][2][4]
The symptoms of pulmonary MAC infection start slowly, get worse over time and may last for weeks to months. People with pulmonary MAC infections may experience cough, weight loss, fever, fatigue, and night sweats.[2]
Symptoms of disseminated MAC infection include: [1][4]
  • Fever
  • Sweating
  • Weight loss
  • Fatigue
  • Diarrhea
  • Shortness of breath
  • Abdominal pain
  • Anemia
People with disseminated MAC infection may also have symptoms associated with an infection of the breast tissue (mastitis); an infection of the skeletal muscle (pyomyositis), abscesses of the skin or brain, and gastrointestinal problems.[1][3] MAC lymphadenitis generally affects children with normal immune systems. Symptoms of MAC lymphadenitis usually only include swollen lymph nodes mainly on one side of the neck.[1][3]
Mycobacterium avium complex (MAC) infections are caused by two types of bacteria: Mycobacterium avium and Mycobacterium intracellulare.[1] These bacteria are found in many places including water (fresh or salt), household dust, and soil. MAC bacteria get into the body when the bacteria are inhaled into the lungs or swallowed. Most people have MAC bacteria in their bodies and never get sick. MAC bacteria primarily cause illness in people who have poorly working immune systems or lung disease. Touching the same objects or having a close relationship with people who are sick from a MAC infection does not seem to increase the chance of getting sick. MAC infections are not thought to be contagious from one person to another.[3][4]
Mycobacterium avium complex (MAC) infection is caused by bacteria and is not an inherited condition. To become infected with MAC bacteria and get sick, a person must first be exposed to one of the associated types of bacteria.[4]
There have been a few reports of families with more than one family member with a MAC infection. In these families, it is thought that there is a variation in a gene or genes involved with the body's immune response. A genetic variant in an immune system gene may make some people more likely to get sick from an infection than others. There are many genes involved in the human immune response, and there is no single gene known to be responsible for MAC infections.[3][4]
Diagnosis of a pulmonary mycobacterium avium complex (MAC) infection is based on a combination of physical exam findings, laboratory test results, and lung x-rays or CT scan results. The laboratory tests include cultures of mucus spit up from the lungs (sputum) and special staining (acid-fast bacillus test). A laboratory culture involves placing cells from a sputum sample in an environment that encourages the bacteria to grow. Results identifying the bacteria may take several days or longer. Because the symptoms of MAC infections are similar to those of other types of infections, other types of infections and diseases must also be ruled out.[3][4]
Diagnosis of disseminated MAC infection is suspected based on symptoms and is confirmed in cultures of blood and often lymph node cells. Cultures of cells from urine, stool, liver or bone marrow may also be helpful. CT scans may be used to try to determine the different sites of infection in the body. If pulmonary or disseminated MAC infection is suspected, an HIV test may be done, as well as other tests, to rule out other associated medical conditions.[1][2][3]
A diagnosis of MAC lymphadenitis is confirmed by finding the bacteria in the culture of lymph node cells. These cells are collected by a biopsy of a swollen lymph node.[2][3]
Mycobacterium avium complex (MAC) infection is classified into several different types including:[2][3]
  • Pulmonary MAC infection, which affects the lungs
  • Disseminated MAC infection, which affects many different parts of the body
  • MAC lymphadenitis, which causes swollen lymph nodes

Treatment options for MAC infections vary by type of infection and by the presence of other medical conditions such as AIDS, cystic fibrosis, COPD, or cancer.[3]

Pulmonary MAC infections and disseminated MAC infections are usually treated with a combination of antibiotic medications. There are many types of antibiotics approved for treating MAC infections A combination of medicines is used because some of the disease-causing Viral infection mac os catalinabacteria can be resistant to certain types of antibiotics. Using more than one antibiotic reduces the chance for the MAC bacteria to come back after treatment is over.[1][3]
For people who have both HIV/AIDS and a MAC infection, treatment usually involves a combination of different antibiotics for the MAC infection and antiretroviral therapy to treat the HIV infection.[1][4]
In special circumstances, there is some evidence to suggest that surgery to remove a single spot of infection in one lung can be helpful in people who have had a poor response to drug therapy. Surgery is usually only done when the infection is found in only one lung and the surgery won't cause any long-term harm.[3][4]
Treatment of MAC lymphadenitis usually involves surgical removal of affected lymph nodes. Antibiotics may also be prescribed depending on the severity of infection and the response to surgery.[3][4]

FDA-Approved Treatments

The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
  • Liposomal amikacin(Brand name: Arikayce) - Manufactured by Insmed Incorporated
    FDA-approved indication: September 2018, liposomal amikacin (Arikayce) was approved for the treatment of Mycobacterium avium complex (MAC) lung disease as part of a combination antibacterial drug regimen in patients who do not achieve negative sputum cultures after a minimum of 6 consecutive months of a multidrug background regimen therapy.
    National Library of Medicine Drug Information Portal
    Medline Plus Health Information
The long-term outlook (prognosis) for people who are sick from mycobacterium avium complex (MAC) infections depends on the type of infection and whether or not the person has other medical conditions or health problems. One published study reviewed the long-term outlook of people with MAC infections with and without other diseases, and found a 75% chance for survival five years after their first diagnosis.[6]
People who are HIV-positive with MAC infections may have a shortened lifespan depending on their immune systems and their response to HIV medications. For people who have had successful treatment, there is still a chance that the infection will come back, so people who have been sick from a MAC infection need to be monitored over time.[2][3]
In HIV-negative people with lung disease from a MAC infection, the treatment success rates range from 20-90% in different studies.[2] People with certain types of lung disease, people who are underweight, and people with anemia are more likely to have a poor outcome than other HIV-negative people affected by a MAC infection.
MAC lymphadenitis in children generally does not impact their health. In some cases, the condition may go away even without treatment.[3]
Viral Infection Mac OS

Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.

Clinical Research Resources

  • ClinicalTrials.gov lists trials that are related to Mycobacterium Avium Complex infections. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
    Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

  • NTM Info & Research (supports pulmonary NTM infections)
    550 Madruga Avenue, Suite 230
    Coral Gables, FL 33146
    Telephone: 305-667-6461, ext 26 and 32
    E-mail: ntmmail@ntminfo.org
    Website: http://www.ntminfo.org/

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In-Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Mycobacterium Avium Complex infections. Click on the link to view a sample search on this topic.
  • The AIDS Education and Training Center (AETC) offers information on Mycobacterium Avium Complex infections. Click on the link to view this information page.

Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.

  1. Currier JS. Mycobacterium avium complex (MAC) infections in HIV-infected patients. UpToDate. 2017; https://www.uptodate.com/contents/mycobacterium-avium-complex-mac-infections-in-hiv-infected-patients.
  2. Griffith DE. Overview of nontuberculous mycobacterial infections in HIV-negative patients. UpToDate. 2017; https://www.uptodate.com/contents/overview-of-nontuberculous-mycobacterial-infections-in-hiv-negative-patients.
  3. Daley CL. Mycobacterium avium Complex Disease. Microbiol Spectr. April, 2017; 5(2):https://www.ncbi.nlm.nih.gov/pubmed/28429679.
  4. Koirala J. Mycobacterium Avium-Intracellulare. Medscape Reference. 2018; http://emedicine.medscape.com/article/222664-overview.
  5. Disseminated mycobacterium avium complex disease. US Department of Health and Human Services. 2017; https://aidsinfo.nih.gov/guidelines/html/4/adult-and-adolescent-opportunistic-infection/326/mac.
  6. Diel R, Lipman M, Hoefsloot W. High mortality in patients with Mycobacterium avium complex lung disease: a systematic review. BMC Infect Dis. 2018; 18(206):1-10. https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-018-3113-x.
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Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Viral Rashes article more useful, or one of our other health articles.


Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.

Viral Skin Infections

In this article

There are many viral skin infections. They range from the common to the rare, from the mild to the severe and from those causing just skin infection to those with associated systemic disease.

Trending Articles

The following is a brief account of a selection of the important viral skin infections. Many of the diseases mentioned here are covered in greater detail elsewhere and the reader is referred to appropriate links.

Nonspecific viral rash

This is a widespread erythematous rash sometimes seen in viral infections. It is accompanied by the common symptoms of a viral infection, such as fever, headache and malaise. The rash usually develops rapidly. The appearance varies but commonly takes the form of an erythematous blotchy eruption.

Local viral infections

Herpes simplex

See separate Herpes Viruses article.

Herpes zoster

See separate Shingles and Shingles Vaccination article.

Molluscum contagiosum

See separate Molluscum Contagiosum article.

Warts

See separate Viral Warts (excluding Verrucae) article.

Orf[1]

  • Orf is contracted from sheep and goats. It is caused by a parapox virus, which infects mainly young lambs and goats who contract the infection from one another (or possibly from persistence of the virus in the pastures).
  • Human lesions are caused by direct inoculation of infected material. It may occur in farmers, butchers, vets, children who bottle-feed lambs and possibly even children who play in pastures where sheep have grazed.
  • The incubation period is five or six days.
  • Lesions are usually solitary but multiple lesions do occur. The lesions are small, firm, red or reddish-blue. They form a lump that enlarges to form a flat-topped, blood-tinged pustule or blister. The fully developed lesion is usually 2 cm or 3 cm in diameter but may be as large as 5 cm.
    Although there appears to be pus under the white skin, incising this will reveal firm, red tissue underneath. The lesion is sometimes irritable during the early stages and is often tender.
  • They usually occur on the fingers, hands or forearms but may be on the face. Red lymph lines may occur on the medial side of the elbow up to the axilla.
  • There may be a mild fever.
  • Allergy to the virus may produce erythema nodosum 10-14 days later.
  • The lesion may be covered to prevent spread, although human-to-human transmission is rare.
  • It resolves spontaneously in 3-6 weeks.
  • A vaccine has been developed to control the infection in sheep.

Viral Infections List

Viral infections that produce rashes

There are a number of viral infections that may cause a rash - most of them typically in childhood. Examples include:

  • Measles.
  • German measles (rubella).
  • Chickenpox (varicella virus).
  • Fifth disease (erythema infectiosum) due to parvovirus.
  • Roseola (erythema subitum, due to herpesvirus 6).
  • Pityriasis rosea (the cause is unknown but it may be caused by herpesvirus types 6 and 7).
  • Echovirus and adenovirus infections often produce a rash.
  • Epstein Barr virus of infectious mononucleosis, (may cause rash but, if amoxicillin or ampicillin is given, there is almost invariably a rash).
  • Primary HIV infection (often associated with a rash).

Other viral infections with skin involvement

Hand, foot and mouth disease

See separate Hand, Foot and Mouth Disease article.

Crosti-Gianotti syndrome[2]

  • This is a response of the skin to viral infection in which there is a papular rash which lasts for several weeks.
  • Other names include papulovesicular acrodermatitis of childhood, papular acrodermatitis of childhood and acrodermatitis papulosa infantum.
  • Causes of the Crosti-Gianotti syndrome include:
    • Echoviruses
  • It affects children aged between 6 and 12 months - females more than males. There may be clusters and a preceding upper respiratory tract infection is not uncommon.
  • A profuse eruption of dull red spots develops over three or four days. They appear first on the thighs and buttocks, then on the outer aspects of the arms and finally on the face, often in an asymmetrical pattern.
  • The spots are 5-10 mm in diameter and a deep red colour. Later they often look purple, especially on the legs, due to leakage of blood from the capillaries. They may develop fluid-filled blisters.

Kaposi's sarcoma

See separate Kaposi's Sarcoma article.

Viral skin infections and sport

Sport increases the risk of transmission of dermatological infections generally. A number of features may predispose to transmission:

  • There may be direct skin-to-skin contact (as in rugby, wrestling on other contact sports).
  • Profuse sweating may cause maceration of skin and provide a portal of entry.
  • Sharing wet areas predisposes to transfer of infection from feet. These include showers and swimming pools. Bare but dry feet, as in judo, other oriental martial arts and gymnastics, are associated with a lower risk of transmission.

Herpes gladiatorum[3]

  • The name implies association with martial arts. In association with rugby it is called 'scrum pox'.
  • Transmission is primarily by direct skin-to-skin contact and abrasions may facilitate a portal of entry. The majority of lesions occur on the head or face, followed by the trunk and extremities.
  • A prodromal itching or burning sensation is followed by clustered vesicles on an erythematous base which heal with crusts over about one to two weeks. Less often, headache, malaise, sore throat and fever may be reported.
  • Recurrent episodes may follow the initial infection.
  • Because of its unusual location, herpes gladiatorum any be confused with impetigo, varicella, staphylococcal furunculosis, or allergic or irritant contact dermatitis.
  • Accurate diagnosis requires viral immunofluorescence and cultures should be obtained by gently breaking an intact vesicle and firmly rubbing the swab tip across the base of the erosion.
  • Treatment of herpes gladiatorum is with oral aciclovir or similar agents and is most effective if commenced at the first symptoms of an outbreak. Topical aciclovir is probably less effective. Any secondary infection should also be treated.
  • The virus can survive for hours to days outside the host if conditions are appropriate. Hence, all contaminated surfaces should be cleaned with antiseptic solution. In the vesicular phase and until the crusts have separated, patients should avoid sports which could involve physical contact.
  • Herpes simplex acquired in sport is often associated with constitutional symptoms.
  • Prophylactic use of valacyclovir has been shown to be efficacious in lowering the incidence of outbreaks of herpes gladiatorum among adolescents at a 28-day wrestling camp[4].

Immune compromise

Viral skin infections tend to be much more aggressive and virulent if the immune system, especially the T-cell system, is inadequate. The classical example is in HIV and skin disease but unusual and gross viral infections of the skin may occur in any condition in which immunity is impaired.

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Viral Infection Mac Os Catalina

  • Viral skin infections; DermNet NZ

How Do You Get Viral Infections

  1. Orf: characteristics and diagnosis; Public Health England

  2. Chuh A, Zawar V, Sciallis GF, et al; Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem, Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious Etiologies? Infect Dis Rep. 2016 Mar 218(1):6418. doi: 10.4081/idr.2016.6418. eCollection 2016 Mar 21.

  3. Thompson AJ, Matinpour K, Hardin J, et al; Molluscum gladiatorum. Dermatol Online J. 2014 Jun 1520(6). pii: 13030/qt0nj121n1.

  4. Anderson BJ, McGuire DP, Reed M, et al; Prophylactic Valacyclovir to Prevent Outbreaks of Primary Herpes Gladiatorum at a 28-Day Wrestling Camp: A 10-Year Review. Clin J Sport Med. 2016 Jul26(4):272-8. doi: 10.1097/JSM.0000000000000255.

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